Sermorelin (GRF 1-29)

Sermorelin is a synthetic peptide made of the first 29 amino acids of human growth hormone-releasing hormone (GHRH). That 29-residue fragment, called GRF 1-29, is the shortest part of GHRH that still carries its full activity at the GHRH receptor in research models. It carries CAS number 86168-78-7 and the molecular formula C149H246N44O42S, with a molecular weight of 3357.9 g/mol.

Because it copies the natural releasing hormone rather than growth hormone itself, sermorelin is studied as a releasing factor: a compound that prompts the body’s own pituitary signaling in model systems. It is supplied as a lyophilized powder for laboratory reconstitution.

Sermorelin acetate held United States marketing approval as a prescription product that was later discontinued. It holds no current approved indication, and the material listed here is a research-grade reference peptide, not that product.

Sermorelin was developed in the 1980s and was studied for decades as a GHRH analog. A foundational overview of growth hormone-releasing hormone by Grossman and Savage appeared in Clinics in Endocrinology and Metabolism in 1986 (PubMed 2429796).

More recent work keeps the GHRH family in view. A 2020 review by Barabutis in Clinical and Experimental Pharmacology and Physiology surveyed the wider GHRH landscape (PubMed 32289177), and a 2021 paper by Memdouh and colleagues in Drug Testing and Analysis covered detection of GHRH synthetic analogs including this class (PubMed 34665524). Most current research interest sits in the broader GHRH literature rather than large new sermorelin trials.

Sermorelin acts at the GHRH receptor on the pituitary, the same target as natural GHRH. In research models it is studied for its ability to prompt pulses of growth hormone release, which is a more physiological pattern than supplying growth hormone directly. Like natural GHRH, it is short-lived because the enzyme DPP-4 degrades it quickly.

This short half-life is the main difference between sermorelin and the stabilized analogs CJC-1295 and tesamorelin, which carry modifications that resist that breakdown. For current findings, search PubMed directly.

Lyophilized sermorelin is stored at -20°C for long-term holding, shielded from light, and repeated freeze-thaw cycles are avoided. Stability for a given lot is documented on its Certificate of Analysis. Refrigeration at 2°C to 8°C suits shorter windows, with the vial protected from light and moisture.

The lot-specific Certificate of Analysis is the authoritative reference for a given batch.

Reconstitution means returning a lyophilized compound to solution. This page gives no preparation procedure: solvent, concentration and handling steps belong to the methodology of the study being reproduced, not to a compound reference. sermorelin is handled as aqueous-soluble material.

Lyophilized material is hygroscopic, so a sealed container is allowed to reach ambient temperature before it is opened. Solubility and water-content figures for a given lot appear on its Certificate of Analysis.

Identity and purity of research-grade sermorelin are established analytically, by HPLC with mass spectrometric confirmation of the expected mass. Verified purity is documented per lot on the Certificate of Analysis. Net peptide content is a useful figure since acetate salt and moisture affect how much peptide is present.

On a Certificate of Analysis, check HPLC purity, mass-spec identity, and net peptide content. peptides.com publishes lot-specific lab reports so buyers can verify material before purchase.

Sermorelin sits within the GHRH and growth-hormone-axis group:

• CJC-1295.
  A stabilized GRF(1-29) analog with a longer half-life. 
• Tesamorelin.
  A stabilized GHRH analog studied in metabolic models.
• Ipamorelin.
  A ghrelin-receptor secretagogue often studied alongside GHRH analogs. 

Grossman A, Savage MO, et al. (1986). Growth hormone-releasing hormone. Clinics in Endocrinology and Metabolism.
PubMed 2429796

Barabutis N (2020). A glimpse at growth hormone-releasing hormone cosmos. Clinical and Experimental Pharmacology and Physiology.
PubMed 32289177

Memdouh S, Gavrilovic I, et al. (2021). Advances in the detection of growth hormone releasing hormone synthetic analogs. Drug Testing and Analysis.
PubMed 34665524

peptides.com carries sermorelin in research-grade lyophilized vials. Each ships with a batch-specific Certificate of Analysis.

• Browse all sermorelin research products
• Catalyst Compounds Sermorelin Acetate
• Real Peptides Sermorelin
• Collections: Research Vials. Documentation: COA and Lab Testing.

These products are sold for Research Use Only and are not intended for human consumption.