AOD-9604 (hGH Fragment 176-191 Analog)

AOD-9604 is a modified fragment of human growth hormone. It corresponds to the C-terminal region of the hGH molecule (residues 176-191) with a tyrosine added at the N-terminus. It carries CAS number 221231-10-3 and the molecular formula C78H123N23O23S2, with a molecular weight of 1815.1 g/mol.

The idea behind the fragment is that this region of growth hormone is studied for effects on fat metabolism in research models, separate from the full hormone’s other actions. It is supplied as a lyophilized powder for laboratory reconstitution.

AOD-9604 came out of work at Monash University in the 1990s on the fat-metabolizing region of growth hormone. A 2006 review by Halford in Current Opinion in Investigational Drugs discussed it among obesity drug candidates in development (PubMed 16625817).

Later literature is largely analytical. A 2013 paper by Orlovius and colleagues in Drug Testing and Analysis examined how AOD-9604 interacts with growth hormone immunoassays (PubMed 24124033), and a 2015 study by Cox and colleagues in the same journal addressed its detection and in-vitro metabolism (PubMed 25208511). Controlled efficacy data in humans is limited.

In research models, AOD-9604 is studied for effects on lipid metabolism that resemble part of growth hormone’s activity without raising IGF-I the way full growth hormone does. The exact receptor interactions are still debated in the literature, and proposed mechanisms center on fat-cell metabolism rather than the growth-hormone receptor pathway used by secretagogues.

This puts AOD-9604 in a different category from the GHRH analogs and ghrelin-receptor secretagogues. For current findings, search PubMed directly.

Lyophilized AOD-9604 is generally stored at -20°C for long-term holding, with stability reported around 24 months. Refrigeration at 2°C to 8°C suits shorter windows, away from light and moisture.

The lot-specific Certificate of Analysis is the authoritative reference for a given batch.

Reconstitution means returning a lyophilized compound to solution. This page gives no preparation procedure: solvent, concentration and handling steps belong to the methodology of the study being reproduced, not to a compound reference. AOD-9604 is handled as aqueous-soluble material.

Lyophilized material is hygroscopic, so a sealed container is allowed to reach ambient temperature before it is opened. Solubility and water-content figures for a given lot appear on its Certificate of Analysis.

Identity and purity of research-grade AOD-9604 are established analytically, by HPLC with mass spectrometric confirmation of the expected mass. Verified purity is documented per lot on the Certificate of Analysis.

Check HPLC purity, mass-spec identity, and net peptide content on the Certificate of Analysis. peptides.com publishes lot-specific lab reports for verification.

AOD-9604 is grouped with the metabolic-context research peptides:

• MOTS-c.
  A mitochondrial-derived peptide studied in metabolic signaling. 
• Tesamorelin.
  A GHRH analog studied around visceral fat in models. 
• Semaglutide.
  A GLP-1 receptor agonist studied in metabolic models.

Halford JC (2006). Obesity drugs in clinical development. Current Opinion in Investigational Drugs.
PubMed 16625817

Orlovius AK, Thomas A, et al. (2013). AOD-9604 does not influence the WADA hGH isoform immunoassay. Drug Testing and Analysis.
PubMed 24124033

Cox HD, Smeal SJ, et al. (2015). Detection and in vitro metabolism of AOD9604. Drug Testing and Analysis.
PubMed 25208511

peptides.com carries AOD-9604 in research-grade lyophilized vials. Each ships with a batch-specific Certificate of Analysis.

• Browse all AOD-9604 research products
• Real Peptides AOD-9604
• Collections: Research Vials. Documentation: COA and Lab Testing.

These products are sold for Research Use Only and are not intended for human consumption.